Reilly's syndrome (page 258) Illustrated Dictionary of Eponymic Syndromes and Diseases and their Synonyms by Stanley Jablonski (National Library of Medicine)
Synonyms: Reilly's phenomenon, splanchnic vasoplegia, sympathetic irritation syndrome
A syndrome in which experimental irritation of the sympathetic nervous system with various agents, such as allergens, bacterial toxins, and physical irritants, produces vasomotor disorders, increased capillary permeability, edema, and lesions of the reticuloendothelial system.
"In addition to bloating and digestive distress, a lot of the patients I see with leaky gut have a combination of other symptoms like food allergies, chronic sinus infections, achy joints, fatigue, brain fog or unexplained rashes. Typically they’ve been to multiple doctors trying to make sense of their symptoms, and conventional tests and imaging studies have been unrevealing. There can be a feeling of hopelessness and despair because the symptoms seem so unrelated." Robynne K. Chutkan, MD, FASGE
Assistant Professor of Medicine, Georgetown University Hospital
Founder and Medical Director, Digestive Center for Women (used as a reference at the web site of Dr. Oz)
I too frequently see patients that suffer with multisystem disease that have seen numerous providers and either had "normal" test results or were simply dismissed. There are strikingly similar complaints in many of my patients.
I look for a preexisting diagnosis of gastroesophageal reflux (GERD) that has not been treated "aggressively" or physical signs suggesting GERD. This may include excessive nasal mucus, post nasal/pharyngeal "stream" of mucus, hoarseness, nasal turbinate hypertrophy, mucus clouded ear drums, tenderness to palpation of the sternum (breast bone), unexplained cough and/or wheezing. Patients may or may not complain of excessive daytime fatigue, insomnia, frequent night time awakenings, recurrent sore throats, sinus infections, persistent relapsing bronchitis/pneumonia and unusual skin rashes including hives (idiopathic urticaria). Harder to understand but often resolved with sucessful treatment are pain syndromes (made worse by central sensitization), unexplained joint pain, neck pain, non-cardiac chest pain, interscapular (dorsal) pain, low back pain/stiffness, recurrent greater trochanteric (hip) bursitis with unexplained radicular "siatic like" leg pain.
